Lumateperone tosylate
CAS No. 1187020-80-9
Lumateperone tosylate ( ITI-007 )
Catalog No. M10638 CAS No. 1187020-80-9
Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 42 | Get Quote |
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10MG | 72 | Get Quote |
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25MG | 147 | Get Quote |
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50MG | 219 | Get Quote |
|
100MG | 323 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameLumateperone tosylate
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NoteResearch use only, not for human use.
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Brief DescriptionLumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
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DescriptionLumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM); also shows affinity for D1; orally bioavailable and exhibits good antipsychotic efficacy in vivo.Schizophrenia Phase 3 Clinical
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SynonymsITI-007
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number1187020-80-9
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Formula Weight565.70
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Molecular FormulaC31H36FN3O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC=C(C=C1)S(=O)(=O)O.CN1CCN2C3CCN(CC3C4=C2C1=CC=C4)CCCC(=O)C5=CC=C(C=C5)F
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Chemical Name1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-, 4-methylbenzenesulfonate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li P, et al. J Med Chem. 2014 Mar 27;57(6):2670-82.
2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.
3. Davis RE, et al. Psychopharmacology (Berl). 2015 Aug;232(15):2863-72.
2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.
3. Davis RE, et al. Psychopharmacology (Berl). 2015 Aug;232(15):2863-72.
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